Simultaneous Fluorescence Sensing of Cys and GSH from Different Emission Channels
2014
A chlorinated coumarin-hemicyanine dye with three potential reaction sites was exploited as fluorescent probe for biothiols. The Cys-induced substitution–rearrangement–cyclization, Hcy-induced substitution–rearrangement, and GSH-induced substitution–cyclizatioin cascades lead to the corresponding amino-coumarin, amino-coumarin-hemicyanine, thiol-coumarin with distinct photophysical properties, enabling Cys and GSH to be selectively detected from different emission channels at two different excitation wavelengths.
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