DISCREPANCIES IN LIPOLYTIC-ACTIVITIES INDUCED BY BETA-ADRENOCEPTOR AGONISTS IN HUMAN AND RAT ADIPOCYTES

A number of catecholamine and non-catecholamine β-adrenoceptor agonists, including the lipolytically selective compound BRL 37344, were compared for lipolytic activity on human and rat adipocytes. It was concluded that (1) human and rat adipocyte β-adrenoceptors mediating lipolysis are not essentially different, (2) partial agonism in human adipocytes is not explained by enhanced re-esterification and (3) BRL 37344 selectively stimulates rat adipocyte lipolysis