Optimization of a Pd-catalyzed intramolecular α-arylation synthesis of tricyclo-[7.3.1.02,7]-trideca-2,4,6-trien-13-ones
2010
Abstract We have optimized the Pd-catalyzed intramolecular α-arylation of 2-(2-halo-benzyl)-cyclohexanones and found that the use of 2-(dicyclohexylphosphino)-2′,4′,6′-tri- i -propyl-1,1′-biphenyl (X-Phos) as an added ligand led to a reproducible, efficient, and scalable synthesis of tricycle-[7.3.1.0 2,7 ]-trideca-2,4,6-trien-13-ones.
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