Effects of heavy ion irradiation on bone metabolism and the related organs

A long-term observation on bones in heavy-ion particle irradiated young rats that immobilized hind limb was performed. The results indicated that bone mineral density (BMD) increased in the 0.5 Gy group, but decreased in the 1.0 Gy and 3.0 Gy. To clarify these findings, a short term observation of 1{approx}14 days after exposure was carried and, to prevent such changes in BMD, bisphosphonate (alendronate) and lactate calcium were administered other irradiated rats for 2 weeks. The BMD increased by both agents, lactate-Ca than alendronate. At present, detailed analyses on biochemical markers such as bone-related hormone and constituents, as well as bone histology, are carrying. A long-term effects of heavy-ion particle exposure to mature rats, 12 months old, 40 rats of each group, were initiated. Shortening of life span of 0.75 Gy and 1.0 Gy radiation groups compared to that of control group were observed. Also, tumors of ovary tended to increase in the 0.75 Gy and 1.0 Gy groups. Histological examinations including bones are carrying now. (author)