inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models

It has historically been debated whether in-flammation plays an active role in Alzheimer’s disease (AD) pathogenesis or is ancillary to other AD pathologies (Wyss-Coray, 2006). How-ever, recent genome-wide association studies linked polymorphisms in inflammation-related genes to increased AD risk, supporting the con-clusion that inflammation can be a causative factor in disease pathology (Karch and Goate, 2015). Notably, variants of the immune cell–specific