AP0815 Allergic sensitization in isolated kidney transplanted patients – Is it a result of immunosuppressive agents or the sensitization of living donor?

Background: Various immunosuppressive drugs are used in the treatment of allergic diseases and suggesting that transplant recipients under immunosuppressive therapy should not develop any sensitizations or show any clinical signs of allergy. Objective: The aim of this study was to evaluate sensitizations and allergy in isolated kidney transplanted children and adolescents under immunosuppressive treatment. Methods: Twenty seven kidney transplanted subjects were studied by standardized interviews International Study of Asthma and Allergies in Childhood criteria, skin prick test (SPT) and measurement of specific immunoglobulin E (s-IgE).  Patient was considered as sensitized when presenting a positive SPT and/or s-IgE >0.35 kUA/l to at least one of the tested allergens. Patients with a history of allergic diseases accompanied sensitization were accepted as allergic. We also performed SPT on the living donors of the allergic groups. Results: Seven patients (25.9%) were found to be sensitized to ≥1 common inhalant and 3 subjects (11.1%) additionally reported a corresponding present history of allergic diseases. All of the living donors’ sensitized patients were allergic. New-onset post-transplantation food allergy was not documented in any patients. Conclusions: This study supports the concept that not only immunosuppressant agents but also the sensitization of living donor is a main contributor to sensitization in isolated kidney recipients.