Variation in vascular permeability in the initial phase of experimental hypertension in the rat

: A transient increase of vascular permeability was observed during the initial phase of renovascular experimental hypertension. The intensity of the permeability-increase varied according to the vascular regions considered: the strongest increase was observed in the aorta-wall; next came the skin, and the smallest increase occurred in the brain. The highest permeability values were observed on the 4th day after induction of hypertension in the brain and in the skin, and on the 7th day only in the aorta. On the 14th day of hypertension, the permeability was back to normal in all the 3 vascular regions studied. Anthocyanoside treatment diminished the permeability increase induced by hypertension. The strongest protective action was observed in the brain, next in the aorta, and it was the weakest in the skin.