Psychotic Episodes in Zarondan Treatment Effects and Side-effects in 105 Patients

SUMMARY The effects and side-effects of treatment with Zarondan in 105 patients with epilepsy are described. In 3 of these patients, five psychotic attacks occurred in close relation to Zarondan treatment. The case histories of, the 3 patients are reported, with special reference to the type of psychosis involved. It is emphasised that the five psychotic episodes were confined to adults, all of whom had previously shown signs of a brittle psychic constitution, but who had not previously manifested psychotic phases. RESUME Les effets desirables et indesirables du traitement par le Zarondan ont ete apprecies chez 105 sujets epileptiques. Chez trois de ces sujets, 5 episodes psychotiques sont survenus en relation etroite avec le traitement. L'histoire de ces 3 patients est rappelee en detail, notamment en ce qui concerne le type de psychose qu'ils ont presente: il est remarquable que les 3 sujets en cause etaient tous adultes et avaient prealablement presente des signes d'une constitution psychique fragile mais sans episodes psychiques caracterises.