Synthesis Techniques of 2-thiophene Ethanol and Its Application in the Medicine

The method for synthesis of 2-thiophene ethanol which is an important medicine intermediate was introduced,such as butyl lithium process,Grignard process,natrium reagent process and reduction ester process.Among them,the first three mutes all took thiopbene as raw material,the metal compounds of thiophene could be obtained through different steps,then reacted with ethylene oxide,and finally hydrolyze into 2-thiophene etha- nol.During reduction ester process,thiophene-acetate was used as raw material,with catalyst,the ester reduced into primary alcohol.The develop- ment,advantages and disadvantages of these methods were summarized,and the prospects and application of 2-thiophane ethanol in the medicament were also summarized,such as thienopyridine,especially ficlopidine and clopidogrel.