De novo biosynthesis and localization of immunoreactive inhibin (10.7 kDa) in normal human stomach

Abstract We have previously reported the occurrence of inhibin — like peptide in gastric juice of normal men. In the present investigation, normal gastric mucosa was shown to synthesize inhibin, in vitro , as measured by 3 H-leucine incorporation (Maximum at 18 h.). Furthermore, the immunohistochemical localization studies demonstrated its presence in the acid secreting parietal cells and basal region of foveolar epithelium of gastric mucosa. Surprisingly, the protein secreting zymogen cells remained unstained.