Preparation method of oriented single alkylation of 4-fluorine-N-isopropyl aniline

The invention discloses a preparation method of 4-fluorine-N-isopropyl aniline by oriented single substituted N-alkylation reaction, which takes 4-fluoroaniline as a substrate, halogenated iso-propane as an alkylation reagent under the effects of a phase-transfer catalyst, a cocatalyst and an acid binding agent. The method has the advantages of mild reaction condition, simple operation, high raw material conversion rate and products selectivity, convenient products separation and the like. The prepared 4-fluorine-N-isopropyl aniline is an important pesticide intermediate, and can synthesize an oxyacetamide herbicide flufenacet and the like.