Synthesis of hexakis(2-keto-3,6-anhydro)cyclomaltohexaose: structural studies and Pb2+ complexation evaluation
2009
Abstract Molecules which scavenge heavy metals are of significant interest for medical applications such as toxic metal decontamination or medical imaging. We report the first synthesis of hexakis(2-keto-3,6-anhydro)cyclomaltohexaose in good yield using mild conditions (Swern oxidation). This potential synthon exhibits reactivity towards water which results in its total conversion into the per( gem -diol) derivative. The first computational study of Pb 2+ complexation with per-3,6-anhydro-α-cyclodextrin in water is also reported.
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