Differentiating true progession from pseudoprogression in patients with gliobastomas using dynamic contrast-enhanced MRI

Objective To investigate the clinical application and manifestation of dynamic contrast-enhanced MRI (DCE-MRI) in differentiating true progession from pseudoprogression in patients with gliobastomas. Methods Twenty five glioma patients were treated with postoperative concurrent chemoradiotherapy and enrolled in this study. All patients were underwent DCE-MRI using a 1.5T scanner. Fifteen patients were confirmed by secondary pathology or clinical and imaging follow-up of patients with gliomas true progession (TP), 10 patients were pseudoprogress (PP). Nonparametric Mann-Whitney test was used to compare perfusion parameters between two groups (TP and PP), were used for receiver operating characteristic (ROC) curve analysis to clear if these parameters can be the indicators to differentiate true progession from pseudoprogression. Results Ktrans(volume transfer constant ), Ve (fractional volume of extravascular extracellular) values between TP and PP glioma groups were statistically significant, Ktransand Ve values were significantly higher in the TP group than in the PP group (P 0.05). Conclusions DCE-MRI can be used to identify glioma TP and PP, Ktrans value and Ve value have clinical significance. Key words: Magnetic resonance imaging; Glioma/DI; Diagnosis, differential