Enantioselective Carbon—Carbon Bond Forming Reactions Using Fluorous Chiral Catalysts.

Abstract Fluorous chiral BINOLs and BINAP were prepared and used as the ligands for an asymmetric addition of Et 2 Zn to aromatic aldehydes and an asymmetric Heck reaction, respectively. The enantioselectivities were similar in homogeneous system to those of the original non-fluorous reactions. Consecutive reactions were examined by utilizing fluorous–organic biphase and fluorous solid phase extraction techniques. Enantioselectivities in consecutive reactions were close to that attained in the non-fluorous system. The solid phase extraction method also enabled us to perform a simultaneous screening procedure.