ABO incompatible live donor renal transplant. Study of 48 patients after desensitization

Abstract Background Until recently, ABO-incompatible living donor kidney transplantation was regarded as an absolute contraindication. However, this kind of kidney transplantation has been used in the last years, with good results. Objetive 0ur objetive is to show the results obtained with this technique in our hospital. Methods Forty-eight patients with a mean age of 50,9 ± 10,9 years were included. Follow-up 44,6 ± 30,9 months. Conditioning: rituximab 375 mg/m², tacrolimus, mycophenolate mofetil or mycophenolate sodium, prednisone, plasmapheresis/immunoadsorption and intravenous immunoglobulin. Accepted IgG and IgM titers for transplantation ≤ 1:8. Results Preprocess IgG titer 1:124 ± 1:40, IgM titer 1:77 ± 1:55. After 6 ± 3 sessions, IgG decreased to Conclusions ABO incompatible living donor kidney transplantation after conditioning with rituximab, plasmapheresis/immunoadsorption and immunoglobulins is a valid option offering excellent outcomes.as survival and acute rejections without increasing infectious complications. An increased tendency towards postoperative bleeding is observed.