at least one chemical entity, pharmaceutical composition, methods for treating a patient, inhibiting at least one enzyme using atp, and treating at least one disease, use of at least one chemical entity, and method for the manufacture of a medicament

AT LEAST ONE CHEMICAL ENTITY, PHARMACEUTICAL COMPOSITION, METHODS TO TREAT A PATIENT, INHIBIT AT LEAST AN ENZYME USING ATP, AND TO TREAT AT LEAST ONE DISEASE, USE AT LEAST ONE CHEMICAL ENTITY, AND THE MEDICINE . Thiotriazole-based chemical entities that exhibit ATP-utilizing enzyme inhibitory activity, methods of using such chemical entities, and compositions comprising such chemical entities are described.