The effect of alprazolam as preoperative adjuvan analgesic on postoperative pain in laparoscopic donor nephrectomy patients

Abstract Objective The aim of this study is to evaluate the effectiveness of alprazolam, administered at different doses for the control of adjuvant analgesia in laparoscopic donor nephrectomy cases preoperatively in the Akdeniz University Organ Transplantation Center, with various pain scales. Material and method Only cases with body mass index ≤ 28 kg/m 2 , age between 18-65 and ASA score 1-2 included in the study. The cases were studied in 3 groups, which were given no alprazolam, given 0.5 mg alprazolam and 1 mg alprazolam in the preoperative period. Collected data were evaluated for preoperative, intraoperative and postoperative periods. Results There were 75 cases; 31 male, 44 female. Mean age was 43.1. Twenty-five cases were detected in all three groups. Mean operation time was 137,8 minutes. There was no statistical difference between the groups in the duration of administered alprazolam before the operation, on the RSS, VAS, NAS scores and duration of administered first analgesic in postoperative period. Additional dose of analgesics were administered in 7, 7 and 11 of cases according to groups; respectively. We found significant difference in group 1 and 2 in blood pressure (p=0,017 and p=0.014). We found significant difference in group 1 in heart rate (p=0,002). Conclusion More effective analgesia protocols need to be identified for pain control in cases of LDN. It is thought that the effectiveness of pain control may increase the number of donors and progress in the treatment of patients with renal failure.