The relationship between acute rejection and infiltration of CD134~+ lymphocytes in heart allografts

Objective To analyze the relationship between survival of allografts and CD134 expression of infiltrating cells.Methods A simplified heterotopic rat heart transplantation model was established,and CD45mAb(1 mg/kg) was intravenously injected or associated with donor splenocytes(1×109 cells/100 g).The transplanted heart harvested and the expression of CD134 in infiltrating cells was performed.Results In normal rat heart,few CD134+ cells could be found.The allografts in CD45mAb or associated donor splenocyte groups had significantly lower CD134+ expression than those treated with splenocytes and no therapy groups.Conclusion These findings suggest that rejection is positively correlated with CD134+ cells.