External validation of a magnetic resonance imaging-based algorithm for prediction of side-specific extracapsular extension in prostate cancer.

Introduction Recently developed algorithm for prediction of side-specific extracapsular extension (ECE) of prostate cancer required validation before being recommended to use. The algorithm assumed that ECE on a particular side was not likely with same side maximum tumor diameter (MTD) 7) the algorithm improved its performance: sensitivity 91%, specificity 47%, PPV 53%, NPV 89%. Conclusions Analyzed algorithm is useful for identifying prostate lobes without ECE and deciding on ipsilateral nerve-sparing technique during radical prostatectomy, especially in patients with GS >7. Due to significant number of false positives in case of: MTD ≥15 mm OR cancer in biopsy ≥15% OR PSA ≥20 ng/mL additional evaluation is necessary to aid decision-making.