Fluoroquinolonas en humor acuoso en pacientes sometidos a cirugía de catarata. Fluoroquinolones in aqueous humor in patients undergoing cataract surgery

Infectious processes such as postsurgical endophthalmitis continue to be one of the most devastating complications of cataract surgery, for this reason the use of broad-spectrum antibiotics would prevent or try to reduce these complications. Objective: to determine the levels of moxifloxacin in aqueous humor previous topical administration 24 or 48 hours to the surgical act. Method: comparative cross-sectional clinical study carried out in the ophthalmology service, University Hospital of Los Andes, in 29 patients who underwent cataract surgery, divided into two groups, according to topical administration of the drug moxifloxacin, 24 or 48 hours prior to surgery, 1 drop was applied every 4 hours, during its preoperative preparation, then 0.1 ml of aqueous humor is taken through a paracentesis. At the beginning of the surgical act, the sample is stored in eppendorf and transferred for processing, each sample taken is processed by capillary electrophoresis with ultra violet detection. Results: the group of topical administration 24 and 48 hours prior to surgery did not obtain statistically significant differences at a 95% confidence level in the absorption of moxifloxacin (p = 0.337) and in the area (p = 0.446), which explains that there are no differences between receiving treatment 24 hours or 48 hours before surgery. Conclusion: The values achieved in both groups do not have statistically significant differences according to their posology to obtain the minimum prophylactic inhibitory concentration.