CDC73 mutations and parafibromin immunohistochemistry in parathyroid tumors: clinical correlations in a single-centre patient cohort

Vito Guarnieri,Claudia Battista,Lucia Anna Muscarella,Michele Bisceglia,Danilo de Martino,Filomena Baorda,Evaristo Maiello,Leonardo DAgruma,Iacopo Chiodini,Celeste Clemente,Salvatore Minisola,Elisabetta Romagnoli,Sabrina Corbetta,Raffaella Viti,Cristina Eller-Vainicher,Anna Spada,Michela Iacobellis,Nazzarena Malavolta,Massimo Carella,Lucie Canaff,Geoffrey N. Hendy,David E. C. Cole,Alfredo Scillitani

CDC73 mutations and parafibromin immunohistochemistry in parathyroid tumors: clinical correlations in a single-centre patient cohort

2012

Objective To determine if molecular and immunohistochemical (IHC) features of the HRPT2/CDC73 gene and its product, parafibromin, predict the natural history of parathyroid malignancy, particularly atypical adenoma, as seen in a single-centre patient cohort.

Keywords:

Cohort
Parathyroid tumors
Malignancy
Atypical Adenoma
Immunohistochemistry
Parafibromin
Pathology
Natural history
Biology
single centre

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