CLINICAL LABORATORY AND IMMUNOLOGICAL CRITERIA FOR THE PROGNOSIS OF PREMATURE BIRTH IN CERVICAL INSUFFICIENCY

The high incidence of premature birth in cervical insufficiency (CVI) makes it relevant to search for markers of prognosis of labor up to 37 weeks in this pathology.Materials and methods. The prospective cohort study included 120 women: the main group – 53 women with CVI and premature birth, the comparison group – 47 patients with CVI and timely birth, the control group – 20 patients without CVI with normal pregnancy. The patients underwent clinical laboratory and immunological examination: general blood test, level of C-reactive protein in blood serum, examination of the total number of leukocytes in cervical mucus, indicators of functional activity and viability of neutrophils, MIP-1β, HMGB1, and MMP8.Results and discussion. The number of stab neutrophils and the level of C-reactive protein, the number of neutrophil extracellular traps (NET) and HMGB1 have predictive value in relation to premature birth in CVI.Conclusion. The criteria for the prognosis of premature birth in women with CVI were identified: an increase in stab neutrophils and C-reactive protein in the blood, the amount of NLV >18%, and the level of HMGB1 >10 ng/L in cervical mucus.