Tierexperimentelle Untersuchungen mit O-(fJ-Hydroxyethyl)-rutosiden bei verringerter Kapillarresistenz - Folgerungen fiir die Klinik Investigations Using O-(p-Hydroxyethyl)-rutosides at Reduced Capillary Resistance in Laboratory Animals - Consequences for the Clinic

The effect of three different oral doses of O-(P-hydroxyethyl)-rutosides (HR = Venoruton®) on the skin capillary resistance (C. R.) of Sprague-Dawley rats, aged 8-10 weeks, 6 months or 1 year (and selected because of their low C. R.) was inves­ tigated. The C. R. was measured over a period of 24 hours after a single adminis­ tration of each dose. The results were compared with a further group aged 6 months who received HR intraperitoneally. The optimal dose was defined in all four groups receiving the drug systemically. In most cases a significant effect could be shown already after 2-4 hours, persisting until at least 8 hours and in some cases 24 hours. Comparative data were also obtained with three different pure hydroxyethyl components (5,7,3',4'-tetra-HR, 5,7,4'-tri-HR, and 7,4'-di-HR) under identical ex­ perimental conditions. Finally, the effect of a single topical application of a gel containing 2% HR was investigated. This produced a significant increase of C. R. after 1 hour which lasted around 4-5 hours. The clinical implications of these results are discussed with special reference to senile, hypertensive and diabetic vascular disease.