TO EVALUATE THE ANTIOXIDANT STATUS IN TYPE 2 DIABETIC PATIENTS WITH OR WITHOUT NEPHROPATHY

Article history Oxidative stress is a condition in which the cellular production of reactive oxygen species (ROS) exceeds the physiological capacity of the antioxidant defense system to render ROS inactivate. Objective: To estimate the levels of Vitamin C and GSH in type 2 diabetic patients. To find out the correlation, if any, between glycemic control and the levels of Vitamin C and GSH. Method: The study was conducted on patients attending rural medical college hospital of India The sample was analysed for estimation of fasting blood glucose, glycated Hb, Vitamin C and GSH. Statistical analysis: Data obtained were analyzed as per standard statistical methods. Results: Out of 150 subjects, Fasting blood glucose (FBG) and glycated hemoglobin was higher in diabetic patients with microalbuminuria than in those without microalbuminuria. Highly significant increase in FBG and HbA1c in non-complicated and complicated cases as compared to healthy controls. Vitamin C level and GSH were significantly decreased in non-complicated and complicated cases. Conclusion: Anti-oxidant levels decrease in diabetic patients,more so with complications. Combinations of antioxidants given as dietary supplements seem to offer the most promising for achieving clinical breakthroughs.