Диагностическое значение изменений уровня белка Клото в крови у пациентов с инфарктом миокарда на фоне различных фенотипов хронической обструктивной болезни легких

The research aimed to analyze Klotho protein level in patients with chronic obstructive pulmonary disease and acute myocardial infarction with various phenotypes of chronic obstructive pulmonary disease. Patients included in the study were divided into groups: the main group – patients with acute myocardial infarction and chronic obstructive pulmonary disease (n = 60) and the comparison group – patients with chronic obstructive pulmonary disease (n = 54). Somatically healthy individuals (n = 30) were examined as a control group. According to the results of the study, it was revealed that in patients with acute myocardial infarction and chronic obstructive pulmonary disease, Klotho protein level was statistically lower compared to the group of patients with chronic obstructive pulmonary disease and in somatically healthy individuals. It was also found that in patients with emphysematous, chronic bronchitis and mixed phenotypes of chronic obstructive pulmonary disease, Klotho protein level has statistically significant differences. The lowest level of studied protein was in patients with chronic bronchitis phenotype. Klotho protein level in the group of patients with acute myocardial infarction with emphysematous, chronic bronchitis and mixed phenotypes of chronic obstructive pulmonary disease was statistically lower than in the group of patients with the chronic obstructive pulmonary disease with corresponding phenotypes. It was also revealed the presence of correlations of Klotho protein level and phenotypes of chronic obstructive pulmonary disease in all the examined patients, with a greater strength of correlations in patients with comorbid pathology.