ИЗМЕНЕНИЕ АКТИВНОСТИ ЛИЗОСОМАЛЬНЫХ ЦИСТЕИНОВЫХ ПРОТЕИНАЗ ПЛАЗМЫ И ЛЕЙКОЦИТОВ КРОВИ В ДИНАМИКЕ ЭКСПЕРИМЕНТАЛЬНОГО ТРОМБОЗА У КРЫС

The activity of the lysosomal cystein proteinases L, B and H in plasma and the various fractions of white blood cells in rats in the dynamics of the experimental venous thrombosis was studied. Venous thrombosis in rats simulated by ligation of the lower iliac vein. Activity of cathepsins on the fi rst, third and fi fth days of the experiment was studied.Statistically signifi cant activity of cathepsins L and H in all cases and cathepsin B on the fi fth day in plasma was increased. Statistically signifi cant activity of cathepsin L on the fi rst day, H on the fi rst and the fi fth, B in the fi rst, third and fi fth day in polymorphonuclear leukocytes was increased. Change of activity cathepsins H and B in mononuclear leukocytes in the fi rst, third and fi fth day was statistically signifi cant. The most pronounced was the increased activity of cathepsin B the polymorphonuclear leukocytes, as well as cathepsins B and H in mononuclear leukocytes. It may testify about active participation of these enzymes in the destructive processes, that lead to the damage of vascular endothelium and determine the severity of the clinical condition.