[Effects of killer immunoglobulin-like receptor and human leukocyte antigen class I ligand on the prognosis of related donor hematopoietic stem cell transplantation].

Objective To study the genotype distribution and the effects of killer immunoglobulin-like receptors(KIR) and human leukocyte antigen(HLA) classⅠligand on related donor hematopoietic stem cell transplantation(HSCT).Metholds The genotypes of donor/ recipient HLA-Cw and donor KIR were determined by polymerase chain reaction-sequence specific primer(PCR-SSP)in 87 cases of related donor HSCT(40 cases were haploidentical HSCT,and the remaining 47 cases were HLA-identital sibling HSCT).Results A1l the donors possessed KIR 2DL1,2DL2/L3,2DL4,3DL2,and 3DL3,and 96.6% of donors possessed 3DL1.The rate of activating KIRs varied.97.7% of the recipients expressed C1,while the rates of C2,Bw4,and HLA-A3/A11 were different.In haploidentical HSCT,KIR-HLA-mismatched group included 34 cases and the matched group included 6 cases.HLA-HLA-mismatched group included 31 cases and the matched group included 9 cases.In matched sibling donor HSCT,KIR-HLA-mismatched group included 42 cases and the matched group included 5 cases.KIR-HLA-mismatched group had higher 2-year disease-free survival(DFS) rate compared with KIR-HLA-matched group [(71.5±6.5)% vs.(50.0±10.7)%,P 0.05 ].Conclusions The rate of activating KIR is lower than inhibitory KIRs.Inhibitory KIR2DL1,3DL1,and 3DL2 may play key roles in the natural killer cell alloreactivity.The DFS rate is higher in KIR-HLA-mismatched group than in KIR-HLA-matched group in related donor HSCT.