Annonaceous acetogenins: Precursors from the seeds of Annona squamosa

Abstract From the less polar fractions of an Annona squamosa (Annonaceae) seeds extract, four new annonaceous acetogenins, dieposabadelin ( 1 ), squamocenin ( 2 ), lepirenin ( 3 ) and dotistenin ( 4 ), were isolated, along with sixteen known acetogenins: corepoxylone, diepomuricanins A and B, dieporeticenine, tripoxyrollin, bullatencin, glabrencin B, reticulatains-1, -2, uvariamicins I, II, III, erythrosolamin, annotemoyin-1 and -2, and solamin. Fourteen are reported for the first time in this species.