Enantioselective Total Synthesis of (-)-Flustramines A, B and (-)-Flustramides A, B via Domino Olefination/Isomerization/Claisen Rearrangement Sequence.

The concise total synthesis of marine alkaloids, (−)-flustramines A and B, and (−)-flustramides A and B has been achieved through the domino olefination/isomerization/Claisen rearrangement (OIC) for highly enantioselective construction of the asymmetric quaternary carbon center and the chemoselective reduction–cyclization (RC) for pyrrolidine formation as key steps.