Management of post bronchoscopic interventional therapy for patients with benign tracheal stenosis: effect of long-term intravenous antibiotics use

Objective To evaluate the efficacy of long-term intravenous antibiotics in the treatment of patients with benign tracheal stenosis after bronchoscopic interventional therapy. Methods Seventy-five patients with benign tracheal stenosis were divided into short-term group and long-term group according to the duration of intravenous antibiotics after bronchoscopic interventional therapy.Patients in short-term group were treated with intravenous antibiotics for less than two weeks.Patients in long-term group were treated with intravenous antibiotics for more than one month.And they also treated with inhalation of amikacin and budesonide suspension for six months during hospitalization and after discharge.The treatment efficacy and complications were evaluated after six months. Results In short-term group, the tracheal diameter increased from (3.81±0.80) mm to (12.55±1.25) mm (t=-46.41, P<0.05), the dyspnea index decreased from 3.41±0.78 to 0.55±0.63 (t=19.53, P<0.05). In long-term group, the tracheal diameter increased from (3.78±0.66) mm to (12.35±1.43) mm (t=-50.60, P<0.05), the dyspnea index decreased from 3.43±0.66 to 0.54±0.51 (t=3.43, P<0.05). The immediate efficacy all reached 100.00% in both two groups.In six months, the overall effective rate in long-term group was higher than that in short-term group (93.48% vs 44.83%, χ2=22.26, P<0.05). There was no complications happened in both two groups. Conclusions Long-term intravenous antibiotic therapy in patients with benign tracheal stenosis after bronchoscopic interventional therapy can reduce the restenosis rate significantly and improve the long-term efficacy. Key words: Benign tracheal stenosis; Respiratory endoscopy; Interventional therapy; Antibiotics; Postoperative management