Antineoplastic compounds, and pharmaceutical use

The present invention discloses compounds of Formula I as a class, wherein, Rl is selected from -H or C1-C6 hydrocarbyl, -NH2, -OH, -O (CH2) nCH3 (n = 0,1 or 2), - N (CH3) 2, or -CH2N (CH3) 2, R2 is selected from α-hydroxy acids or amino acid or α -OH (R1, R2 are not simultaneously -CH3 and -OH), wherein X, Y is -H, -CH3 , -CH2OH, -CH (OH) CH3, -CH2SH, -CH (CH3) 2, -CH2CH (CH3) 2, -CH (CH3) CH2CH3, -CH2CH2SCH3, -CH2COOH, -CH2CONH2, -CH2CH2COOH, -CH2CH2CH2CH2NH2, or -CH2CH2CONH2, R3-R5 are H or C1-C6 hydrocarbon. Such compounds minimal toxicity, significantly inhibited tumor cell migration and invasion in vitro, and having a lower concentration i.e. inhibit metastasis of tumors in mice in vivo, but also exhibit the cytotoxic anticancer drugs such as taxol significantly sensitized effect.