Synergistic anti-viral effect of oxanosine and ddI against human immunodeficiency virus.

Abstract The combined effect against human immunodeficiency virus (HIV) of oxanosine and 2′3′-dideoxyinosine (ddI) has been evaluated by the production of viral particles, the expression of viral antigens on cell surfaces, and the amount of viral genome integrated in the host cells. Oxanosine alone has no effect on HIV replication up to 100 µg/ml, however, in the presence of ddI, oxanosine revealed concentration dependent inhibition against HIV without cytotoxicity.