An efficient, microwave-assisted, one-pot synthesis of novel 5,6,7,8-tetrahydroquinoline-3-carbonitriles

An efficient, microwave-assisted synthesis of novel 2-alkoxy-5,6,7,8- -tetrahydroquinoline-3-carbonitriles, which have not hitherto been reported, via reactions of cyclohexanone and arylidene malononitriles in the corresponding alcohols in presence of sodium is described. All the newly synthesized com- pounds were characterized by the IR, 1 H-NMR, 13 C-NMR and mass spectres- copic techniques and by elemental analyses. The newly synthesized com- pounds were evaluated for their antibacterial and antifungal activities.