Aminopyrimidines: Recent synthetic procedures and anticancer activities

Abstract The pyrimidine scaffold represents one of the privileged structures in chemistry, and there has been an increase in number of studies utilizing this scaffold and its derivatives. The review compiles the strategies and methods of development of aminopyrimidine derivatives. The advances in organic and heterocyclic chemistry are considered in the targeted synthesis of aminopyrimidine derivatives whose series contains the most demanded and efficient antitumor pharmaceuticals. Optimization of synthetic protocols of cyclocondensation reaction and implement multicomponent reactions have been performed to obtain desired aminopyrimidines. In addition, this review aims to be a comprehensive and general summary of numerous aminopyrimidines, their use as medicinal agents and their main anticancer activities.