The serotonergic system in Alzheimer’s Disease

AlzheimerÂ’s disease (AD) is one of the most common neurodegenerative diseases throughout the world that impairs brain regions related to learning and memory. Several neurotransmitter systems, especially the serotonergic system take part in cognitive processes, and the neurochemistry of AD patients is affected by AD-associated neurodegeneration. Serotonergic markers are located in diverse brain areas mostly related learning and memory. Therefore the serotonergic neurotransmission is very important in memory. Remarkable changes occur in the serotonergic system because of AD. Since AD is a progressive and irreversible disorder and there is no specific treatment for this disease, the number of patients is rapidly increasing. In this review, the relationship between AD and the serotonergic system is described in general terms. Especially serotonin (5-HT) receptors that take part in cognitive dysfunctions have examined in this study.