Fluorine-containing organozinc reagents. V.: The reformatskii-claisen reaction of chlorodifluoroacetic acid derivatives

Abstract Silicon induced Reformatskii-Claisen reaction of allyl chlorodifluoroacetate ( 1 ) affords 2,2-difluoro-4-pentenoic acid ( 2 ) in good yields. Starting from inexpensive chloro-difluoroacetic acid, a variety of useful fluorine-containing synthetic building blocks can be obtained under the same reaction conditions.