Effect of landiolol on bispectral index scores in patients undergoing lower abdominal surgery

BACKGROUND: The aim of this study was to examine the effects of landiolol on bispectral index scores (BIS) during surgery. METHODS: Twenty patients undergoing total hysterectomy were allocated into two groups; 1) 10 patients not receiving landiolol (C group), 2) 10 patients receiving landiolol 125 microg x kg(-1) x min(-1) for one minute followed by 40 microg x kg(-1) x min(-1) (L group). They were anesthetized with sevoflurane (end-tidal concentration of 1.0%) combined with a continuous infusion of remifentanil at 0.25 microg x kg(-1) x min(-1). Mean arterial pressure (MAP), heart rate (HR) and BIS were recorded 4 times (immediately before the skin incision, 5 minutes after the skin incision, at the moment of uterine extraction and during retroperitoneal closure). RESULTS: No significant differences were found in MAP and BIS between the groups at any time points, while HR in the L groups was lower than that in the C group throughout the study period. CONCLUSIONS: This study suggests that landiolol has no effects on BIS in patients undergoing lower abdominal surgery during sevoflurane-remifentanil anesthesia.