Effect of ivermectin against subperiodic Brugia malayi infection in the leaf monkey, Presbytis cristata

Invermectin at single doses of 0.2–1.0 mg/kg body weight reduced the microfilarial counts of subperiodic Brugia malayi in Presbytis cristata by 59.9%–89.6% of initial counts, 4 weeks after treatment. Adult filaricidal activity was poor, live adult worms being recovered from all animals at autopsy. There was no serious side effect at these doses.