Synthesis and Antibacterial Activity of New 1,4-Disubstituted Piperazine Derivatives

In search of antibacterial agents new 4-phenylpiperazine derivatives were obtained. Their structures include some heterocyclic (thiazole, oxadiazole, piperazine, and benzimidazole) systems, as well as functional (thioamide and amidoxime) groups, frequently present in biologically active compounds. Thioamides 2b , e and amidoximes 3b – e were examined towards 25 strains of aerobic and 25 strains of anaerobic bacteria. The derivatives 2e and 3b showed the highest antimicrobial activity towards anaerobes, both Gram-negative and Gram-positive. The compounds studied were inactive towards the aerobes, however. Their tuberculostatic activity towards the standard H37Rv strain and two strains isolated from tuberculotic patients was studied in vitro. The obtained MIC values were within the limits 12.5–100μ g/mL.