The Application of Intravoxel Incoherent Motion Diffusion-Weighted Imaging in the Diagnosis of Hilar Obstructive Jaundice

OBJECTIVE: The aim of this study was to investigate the potential of intravoxel incoherent motion diffusion-weighted imaging in diagnosing hilar obstructive jaundice. METHODS: Fifty-nine patients diagnosed with hilar obstructive jaundice were enrolled in our hospital form January 2017 to January 2018. All the patients received scanning by a 3.0-T nuclear magnetic resonance scanner. The values of apparent diffusion coefficient (ADC)slow, ADCfast, and f were obtained and analyzed by 2 experienced radiologists. The differences between patients with hilar biliary obstruction and healthy volunteers in ADCslow, ADCfast, and f values were analyzed. Moreover, the differences between benign and malignant obstructive jaundice in ADCslow, ADCfast, and f values were analyzed. According to the serum levels of total bilirubin, patients were divided into 3 groups: mild, moderate, and severe obstructive jaundice. The differences between the 3 groups in ADCslow, ADCfast, and f values were also analyzed. RESULTS: The ADCfast values were obviously lower in patients with hilar obstructive jaundice than in healthy controls, whereas no significant difference in the values of ADCslow and f was found between both groups. The optimal cutoff value for ADCfast was 0.0341. The ADCfast values were significantly different between patients with benign and malignant hilar obstructive jaundice. The ADCfast values were negatively associated with the severity of hilar obstructive jaundice. CONCLUSIONS: Intravoxel incoherent motion diffusion-weighted imaging was a promising method for diagnosing hilar biliary obstruction jaundice.