Studies of magnesium - hydroxyapatite micro/nano film for drug sustained release

Abstract It is challenging to fabricate the bioactive films containing magnesium (Mg) particles to take full advantage of this characteristic of Mg to obtain a film with porous structure. Mg-doped hydroxyapatite (Mg-HA) film with uniform distribution of Mg particles are obtained by pulsed laser deposition. In the simulated body fluids, the Mg in the Mg-HA film is preferentially degraded for ion exchange, and the microporous structures are formed into the surface of the Mg-HA film after 7 days. These microporous structures facilitate the diffusion of the drug covered by the Mg-HA film to achieve sustainable drug release. Herein, ciprofloxacin hydrochloride (CIP) film as the drug representative is obtained by low energy electron beam deposition (LEBD) to verify the sustained release effect of Mg-HA film. Therefore, the four-layer composite films with a distribution of the CIP are obtained using the layered growth of CIP film and Mg-HA film by the PLD-LEBD coupling technology. The results showed that Mg-HA film not only prolonged the CIP release period, but also enhanced the drug release in the middle and late stage. Furthermore, the application of Mg-HA film to implant surface modification can not only exert excellent antibacterial effect, but also promote bone healing.