Elimination of atracurium in humans: contribution of Hofmann elimination and ester hydrolysis versus organ-based elimination
1986
Atracurium, a nondepolarizing muscle relaxant, is eliminated through several pathways, including Hofmann elimination (spontaneous degradation in plasma and tissue at normal body pH and temperature) and ester hydrolysis (catalysis by nonspecific esterases). Because elimination of atracurium occurs in
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