Ontheorigin ofdeletions andpoint mutations inDuchenne muscular dystrophy: mostdeletions ariseinoogenesisand mostpointmutations result fromeventsinspermatogenesis

We presenttheresults ofastudyofthe rateandorigin ofmutations inDuchenne musculardystrophy (DMD).Depending onthetypeofmutation(deletion/duplication orpointmutation) present inthe patient, therearewidely varying ratios of maletofemalemutationrates.Indeletions, themalemutationrateisonly30% ofthefemaleone.In non-deletional/ non-duplicational mutations (presumably