F-54 The causing pathogen of bacterial pneumonia in patients with respiratory viral infection varies according to the type of virus

After respiratory viral infection, post-viral bacterial pneumonia often develops.Except influenza virus,predominant bacteria are not known in post-viral bacterial pneumonia.We studied to know whether there is a difference in the cause of post-viral bacterial pneumonia according to the type of respiratory virus.From 2013 to 2016,at Ulsan,multiplex PCR(for simultaneous detection 7 respiratory viruses)had been done in patients with respiratory symptoms.The radiologic evidence of pneumonia was evaluated through CXR/CT.The patients`medical records including results of sputum and blood culture(done in 48hours after hospital visit) were reviewed. Respiratory viruses were detected in 3327/5297 patients and 706/3327 patients had infiltrations in CXR/CT.Clinically significant bacteria were identified in 252/706 patients.Under 16years[136/252,(54.0%)],Mycoplasma was the most frequent bacterium,regardless of the preceding virus type. In 16 and over 16years[116/252,(46.0%)],Influenza A(n=21) preceded post-viral bacterial pneumonia of S.aureus(6/21),Klebsiella(4/21),S.pneumoniae(3/21),Acinetobacter spp. (3/21), Human rhinovirus(n=24) preceded that of S.aureus(7/24),Klebsiella(3/24),Chlamydia(3/24),Pseudomonas spp.(3/24), Human metapneumovirus(n=20) preceded that of S.aureus(4/20),Klebsiella(4/20),Acinetobacter spp.(4/20),Coronavirus(n=13) preceded that of Klebsiella(3/13),Acinetobacter spp.(3/13),RSV(n=13) preceded that of E.coli(3/13),Acinetobacter spp.(3/13) (P<0.001). The causing pathogens of post-viral bacterial pneumonia are different according to type of culprit respiratory viruses.