SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NOVEL 1,2,4-TRIAZOLE [3,4-B][1,3,4] THIADIAZOLE DERIVATIVES

Several 3,6-disubstituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles were prepared by condensation of 4- amino-5-(2-(4-isobutyl phenyl) propyl)-4H-1,2,4-triazole-3-thiol (4) with acetic acid, substituted aromatic acids, phenyl isothiocynate, pyridine and urea through a one-pot reaction. These compounds were investigated for their antibacterial, antifungal, analgesic and antihelmentic. Some compound showed analgesic activity as compared to ibuprofen. Some of the tested compounds also showed moderate antimicrobial activity against tested bacterial and fungal strains. These compound show better antihelmentic activity as compared to albendazole.