Copper nanoparticles catalyzed N-H functionalization: An efficient solvent-free N-tert-butyloxycarbonylation strategy

Abstract A chemoselective transformation of amines to their tert- butyloxycarbonyl (Boc) protected derivatives ( N Boc) is described using Cu-NPs under solvent-free conditions. Simple method, rapid reaction rate, mild conditions, tolerance of a wide range of functional groups, excellent yield, ease recovery and high catalytic turnover are the salient features of this approach. tert- Butyloxycarbonylation of chiral amino acid esters and amino alcohols were performed without racemization.