Behavior of total IgE in normal and atopic subjects of various ages

: We have determined total IgE in serum of 640 healthy subjects and 620 atopic asthmatic subjects of both sexes, aged between 1 and 70. Values of antibody E after decimal logarithmic transformation have acquired a path as in Gaussian curves. Healthy subjects, chosen for sex and for unit of ten years of life, constantly show mean values in serum have appeared in the first and second decade of life in males; in second and third in females. Those facts should be originated by genetic factors connected with sex. We have described physiopathological conditions in which an increase of serum IgE could be connected with genetic factors and mechanism ascertained today, both responsible for the control of IgE.