Total Synthesis of GKK1032A2 via Direct 13‐Membered Macrocyclization Using a Nucleophilic Aromatic Substitution of an (η6‐Arene)Chromium Complex

The first enantioselective total synthesis of GKK1032A2 has been achieved. The key step is a direct construction of the highly strained 13-membered macrocycle of GKK1032A2 by an intramolecular nucleophilic aromatic substitution (SNAr) reaction. This is the first successful example of construction of a macrocycle with an aryl ether linkage utilizing an intramolecular SNAr reaction of an (η6-arene)chromium complex.