The use of pharmacokinetics in chronic toxicity testing

The usefulness of a unified pharmacokinetic model for the chronic testing of drug residues is described. The model was very suitable for the disposition and metabolism rate of methylch1oroform (MC) in humans, rats and mice, at various exposure levels and with two different routes of administration. The physiological parameters fed into the model take account of old and young animals. The model could provide more reliable estimations of health hazards for the chemicals in our environment.