Effects of the renin inhibitor N-[N-(3-(4-amino-1-piperidinyl-carbonyl)-2(R)-benzylpropionyl)-L- histid inyl] -(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6(2-pyridyl)-hexane-2-amide acetate in anesthetized rhesus monkeys.

The renin inhibitory effect of the non-peptide renin inhibitor S 2864 (N-[N-(3-(4-Amino-1-pipetzidinyl-carbonyl)-2(R)-benzylptzopionyl)-L-histidinyl]- (S, 3R, 4S)-1-cyclohexyl-3,4-dihydroxy-6 (2-pyridyl) -hexane-2-amide acetate, CAS 135683-92-0) was characterized in vitro and in vivo in primates. In vitro, S 2864 inhibited the activity of purified human plasma renin with an IC 50 of 3.8×10 -10 mol/l and did not affect related human aspartyl proteases like human cathepsin E, cathepsin D or pepsin